DISCOVER A BETTER WAY
Achieve consistent bioprocessing with TRIS AMINO buffers and derivatives from ANGUS Chemical Company

Spectrum Chemical is proud to offer a curated portfolio of TRIS buffers from ANGUS Chemical Company. From early-stage biopharmaceutical development through commercialization, ANGUS’ high-purity, cGMP-compliant TRIS AMINO buffers and TRIS derivatives help the world’s leading biopharmaceutical companies achieve the most consistent, cost-effective manufacturing processes. The company innovated the Tromethamine molecule more than 70 years ago, proudly building the TRIS brand to represent a strong history of quality and reliability. ANGUS remains the world’s largest and only full integrated manufacturer of TRIS tromethamine buffers, providing 100% traceability and secure, sustainable supply.


 TRIS AMINO™ AC Ultra Pure

Less Clumping. More Preparation Efficiency.

While most TRIS buffers are prone to clumping and hardness, the next-generation TRIS AMINO™ AC buffers feature a unique crystal morphology that results in less time, energy and cost to break up clumps prior to buffer preparation.

TRIS AMINO AC uses a proprietary process technology that produces a larger, more rounded particle. Without making any changes to the molecule itself, this process helps prevent the formation of strong, hard cakes even when subjected to a variety of packaging, shipping and storage conditions.

  • Low interparticle cohesion between crystals requires less energy to break up clumps
  • More spherical crystals for easy dispensing and transport through conveyors
  • Fewer fine particles for lower dust emissions
  • No additives or anti-clumping agents
  • Highest purity and testing requirements including bioburden and endotoxin
  • cGMP-compliant with comprehensive validation documentation
  • Proven safe use in commercial drug products
  • Fully traceable supply chain with line of sight to the base materials
  • Elemental impurity risk assessment using ICP-MS technology
  • Ability to maintain pH from 7 to 9 by utilizing a combination of free base and its salts
  • Amine and alcohol functionality to provide versatile chemical reactivity

Typical Properties*

Purity

99.9%

Molecular weight 

121.14

Melting point 

168-172°C

pKa @ 20°C

8.3

pKa @ 37°C

7.8

pKa/°C

-0.03

pH of 0.1M aqueous solution (20°C)

10.4

Δ pH/10X dilution

-0.05 to -0.10

*Values shown are typical properties and are not to be considered product specifications. Test methods available upon request.

An Innovative Solution to a Long-standing Industry Problem

Clumping during transport and storage is a well-known and challenging characteristic of conventional TRIS buffer products. To address this long-standing industry challenge, ANGUS Chemical Company developed the next generation TRIS AMINO™ AC Advanced Crystals, produced in our newly expanded, state-of-the art manufacturing facility in Ibbenbüren, Germany.

Conventional TRIS crystal structure*

TRIS AMINO AC Advanced Crystals

Larger Size, Fewer Fine Particles, Smoother Surface = Less Clumping. The unique morphology of TRIS AMINO AC buffers helps reduce cake strength, resulting in less clumping and hardness. 4x magnification at 2 cm observation distance

Uses and Applications

  • Pharmaceutical raw material compliant with USP, EP, JPC, and ChP monographs
  • Commercial purification (downstream processing) of biological molecules including monoclonal antibodies and recombinant proteins
  • Processing aid for insulin manufacturing
  • Non-sterile pharmaceutical excipient
  • Buffer for molecular biology and clinical diagnostic applications
  • pH buffering of enzymes in biotechnology applications
  • Small mlecule API salt to systematically adjust drug hydrophilicity
  • Small molecule synthesis building block

Chemical Name: Tris(hydroxymethyl)aminomethane (2-amino-2-(hydroxymethyl)-1,3-propanediol)

Common Synonyms: TRIS, Tromethamine, Trometamol, THAM, Tris base, TRIZMA®

Product Information

Chemical Type Chemical Name CAS No. Catalog No. Size

Buffer

TRIS AMINO AC Ultra Pure USP, EP Biologics Grade

77-86-1

376127

5 KG

376126

12 KG

375907

25 KG


BIS-TRIS Biologics Grade

Exceptional Purity. Diverse Applications.

BIS-TRIS Biologics Grade buffer from ANGUS Chemical Company is a 99.0% pure buffering agent widely used as a diagnostic reagent and in gel electrophoresis separations, cell culture and bioprocessing applications. BIS-TRIS is ideal for a variety of biological-based formulations and nucleic acid systems and is known to complex with various metals.

  • High purity, 99.0%
  • Produced under a single global quality system that includes ISO 9001:2015
  • Proven safe use in commercial drug products
  • Highly soluble in water
  • Ideal for use as an alternative to cacodylate, maleic acid and citrate

 Uses and Applications

  • Purification of biological molecules (downstream processing)
  • Raw materials for API/drug substance formulation
  • Cell culture buffer
  • Fractionation of hemoglobin
  • Gel electrophoresis
  • Diagnostics reagents
  • Research and development buffer (R&D)
  • Analytical chromatography
  • Non-sterile excipient

Typical Properties*

Purity

99.0%

Molecular weight 

209.24

Melting point 

100.0 –104.0°C

pH (1.0M aqueous solution @25°C):

9.5 – 11.0

Working pH Range:

5.8 – 7.2

pKa @ 20°C:

6.35 – 6.65

*Values shown are typical properties and are not to be considered product specifications. Test methods available upon request.

ANGUS, TRIS AMIONO and DISCOVER A BETTER WAY are trademarks of ANGUS Chemical Company.

Chemical Name: Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane

Common Synonyms: BIS TRIS, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, 2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol

Product Information

Chemical Type Chemical Name CAS No. Catalog No. Size

Buffer

BIS-TRIS Biologics Grade

6976-37-0

376043

5 KG

376042

12 KG

376041

25 KG


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Spectrum has been serving compounders and scientists for nearly five decades, and we've earned the trust of quality-driven industries by continually investing in our infrastructure, instrumentation, regulatory compliance and personnel. We know that our chemical products are only as good as the analytical tests and documentation prove them to be. We perform more than 20,000 analytical tests per year in our 4 globally-located analytical laboratories. Spectrum has been a privately-owned business since 1971, treating our employees and customers as part of the Spectrum family all along. Through this dedication, we have earned the trust of tens of thousands of loyal customers. Spectrum understands the cost concerns of our customers and is committed to providing the highest quality of products and the most competitive prices to our quality-driven customers.